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・ Protein folding
・ Protein footprinting
・ Protein fragment library
・ Protein function prediction
・ Protein G
・ Protein geranylgeranyltransferase type I
・ Protein geranylgeranyltransferase type II
・ Protein histidine kinase
・ Protein I-sites
・ Protein IB5
・ Protein Information Resource
・ Protein inhibitor of activated STAT
・ Protein inhibitor of activated STAT2
・ Protein isoform
・ Protein K
Protein K (gene expression)
・ Protein K (porin)
・ Protein kinase
・ Protein kinase A
・ Protein kinase B
・ Protein kinase C
・ Protein kinase C zeta type
・ Protein kinase D1
・ Protein kinase domain
・ Protein kinase inhibitor
・ Protein kinase N1
・ Protein kinase R
・ Protein kinase, AMP-activated, alpha 1
・ Protein L
・ Protein ligand


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Protein K (gene expression) : ウィキペディア英語版
Protein K (gene expression)

Protein K is a human protein found in the cell nucleus that binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. The simian homolog is known as ''protein H16''. Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein responsible for most gene transcription. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.〔Gaillard C, Cabannes E, Strauss F. (1994). Identity of the RNA-binding protein K of hnRNP particles with protein H16, a sequence-specific single strand DNA-binding protein. ''Nucleic Acids Res'' 22(20):4183-4186.〕
RNA binding protein domains in other proteins that are similar to the RNA binding domain of protein K are called K-homology or KH domains.
Protein K has been the subject of study related to colorectal cancer, in which an RNA editing event inducing the expression of an isoform containing a point mutation was found to be specific to cancerous cells.〔Klimek-Tomczak K, Mikula M, Dzwonek A, Paziewska A, Karczmarski J, Hennig E, Bujnicki JM, Bragoszewski P, Denisenko O, Bomsztyk K, Ostrowski J. (2006). Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa. ''Br J Cancer'' 94(4):586-92.〕
==Human proteins containing KH domain==

AKAP1; ANKHD1; ANKRD17; ASCC1; BICC1; DDX43; DDX53; DPPA5;
FMR1; FUBP1; FUBP3; FXR1; FXR2; HDLBP; HNRPK; IGF2BP1;
IGF2BP2; IGF2BP3; KHDRBS1; KHDRBS2; KHDRBS3; KHSRP; KRR1; MEX3A;
MEX3B; MEX3C; MEX3D; NOVA1; NOVA2; PCBP1; PCBP2; PCBP3;
PCBP4; PNO1; PNPT1; QKI; SF1; TDRKH;

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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